A Protein A based affinity membrane chromatography product for capture-step antibody purification, Purexa PrA utilizes a convection-based mechanism to improve efficiency, purity and yield. It separates target antibodies from the residual DNA and host cell proteins while utilizing affinity-based chromatography. Compared to magnetic and resin beads, Purexa PrA affinity membrane chromatography is unaffected by pore diffusion and has no incubation time with overall shorter processing times. Purexa PrA can operate at rapid flow rates to enhance productivity while maintaining high purity eluates.